4-Methylmorpholine → HCID 86696414, compound

Participants

Reaction Steps

Ethyl chloroformate [541-41-3] (1.4 mL, 14.7 mmol) was added to an ambient temperature solution of 2,2,2-trifluoro-N-(2-phenylamino-ethyl)-acetamide (3.4 g, 14.6 mmol) and N-methyl morpholine [109-02-4] (2.0 mL, 17.7 mmol) in ethyl acetate (145 mL) and stirred under N2 blanket for 17 h. The reaction suspension was then washed with dilute aqueous hydrochloric acid, brine, dried (MgSO4), evaporated and carried on to the next synthetic step without further isolation.

Provenance & Evidence