Sodium hydride → HCID 86696419, compound

Participants

Reaction Steps

To a solution of 2-((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)ethanol (0.35 g, 1.5 mmol) and 1-(tert-butyl(methyl)carbamoyl)-3-methyl-1H-imidazol-3-ium (0.30 g, 1.5 mmol) in THF/DMF (6.0 mL/3.0 mL) was added NaH (0.15 g, 60% in mineral oil, 2.5 mmol). The reaction was stirred for 24 h and then quenched with water, extracted with ether, concentrated and purified by ISCO column chromatography give 2-((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)ethyl tert-butyl(methyl)carbamate as product (0.17 g, 31% yield). LRMS (ESI) m/e 372.0 [(M+H)+, calcd for C14H21BrN5O2 371.2].

Provenance & Evidence