HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(tert-Butoxycarbonylaminomethyl)phenylboronic acid → Tert-butyl 4-(6-((2-(cyclopentyloxy)ethyl)amino)imidazo[1,2-b]pyridazin-3-yl)benzylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(tert-Butoxycarbonylaminomethyl)phenylboronic acid | HCID 3863163 | — |
| Reactant | 3-bromo-N-(2-(cyclopentyloxy)ethyl)imidazo[1,2-b]pyridazin-6-amine | HCID 86696422 | — |
| Product | Tert-butyl 4-(6-((2-(cyclopentyloxy)ethyl)amino)imidazo[1,2-b]pyridazin-3-yl)benzylcarbamate | HCID 86696423 | 70% |
Reaction Steps
The 3-bromo-N-(2-(cyclopentyloxy)ethyl)imidazo[1,2-b]pyridazin-6-amine was coupled with (4-(((tert-butoxycarbonyl)amino)methyl)phenyl)boronic acid under the Suzuki coupling conditions as described in example 5.6.76, Part B to obtain 70% product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969565B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-e48d372006584011a22754f4518a330c |
| Source note | uspto-grants-2015_03 |