Potassium Carbonate → HCID 71727039, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[2-(3-bromo-imidazo[1,2-b]pyridazin-6-ylamino)-ethyl]-3-tert-butyl-imidazolidin-2-one (75 mg, 0.2 mmol), (4-aminomethylphenyl)boronic acid hydrochloride (49 mg, 0.26 mmol), K2CO3 (83 mg, 0.6 mmol) and dichlorobis(triphenylphosphine)palladium(II) (7 mg, 0.01 mmol) in MeCN/water (2.8 ml/0.7 ml) was heated in a microwave at 150° C. for 15 min. The reaction mixture was diluted with MeCN and filtered. The filtrate was subjected to preparative HPLC to give the titled compound (64.8 mg). 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.26 (s, 9H) 3.24-3.31 (m, 4H) 3.40 (t, J=5.95 Hz, 2H) 3.52 (t, J=5.95 Hz, 2H) 4.17 (s, 2H) 6.70 (d, J=9.70 Hz, 1H) 7.54-7.63 (m, 3H) 7.77 (s, 1H) 8.19-8.23 (m, 2H) 8.56 (s, 1H). LRMS (ESI) m/z 408.4 [(M+H)]+, calc'd for C22H29N7O: 407.52.

Provenance & Evidence