Acetyl chloride → Hydrochloric Acid

Participants

Reaction Steps

To a solution of (S)-tert-butyl 2-(((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)methyl)pyrrolidine-1-carboxylate (13.4 g, 33.8 mmol) in MeOH (100 mL) was cooled to 0° C. and added acetyl chloride (24 mL, 338 mL) dropwise. The reaction was warmed to rt and stirred for overnight, and concentrated to give (S)-3-bromo-N-(pyrrolidin-2-ylmethyl)imidazo[1,2-b]pyridazin-6-amine as HCl salt (11 g, 100% yield). LRMS (ESI) m/e 298.0 [(M+H)+, calcd for C11H15BrN5 298.2].

Provenance & Evidence