Phenylboronic Acid → HCID 86696452, compound

Participants

Reaction Steps

4-(3-Phenyl-imidazo[1,2-b]pyridazin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester was prepared using the approach described in example 5.6.112 from 4-(3-iodo-imidazo[1,2-b]pyridazin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester (513.4 mg, 1.2 mmol) and phenyl boronic acid [98-80-6] (178.3 mg, 1.5 mmol) to obtain 220.2 mg of white powder, mp. 101-103° C. (dec.). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.44 (s, 9H) 3.52 (br. s., 8H) 7.22 (d, J=9.85 Hz, 1H) 7.31-7.37 (m, 1H) 7.46-7.54 (m, 2H) 7.95 (d, J=10.11 Hz, 1H) 8.00 (s, 1H) 8.11-8.18 (m, 2H). 13C NMR (100 MHz, DMSO-d6) δ ppm 28.03, 42.73, 45.56, 79.08, 110.13, 125.75, 126.24, 126.93, 127.14, 128.61, 129.03, 131.07, 137.15, 153.85, 154.63. LRMS (ESI) m/z 411.3 [(M+H)]+, calc'd for C21H25N5O2: 379.47.

Provenance & Evidence