Hydrochloric Acid → HCID 86696476, compound

Participants

Reaction Steps

Prepared from 4-[3-(2-methoxy-pyridin-3-yl)-imidazo[1,2-b]pyridazin-6-yl]-piperazine-1-carboxylic acid isopropyl ester by hydrochloric acid hydrolysis in methanol to provide 4-[3-(2-methoxy-pyridin-3-yl)-imidazo[1,2-b]pyridazin-6-yl]-piperazine-1-carboxylic acid isopropyl ester di-hydrochloride as a white powder, mp. 275-276° C. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.15 (d, J=6.06 Hz, 5H) 3.51 (br. s., 7H) 4.37 (s, 4H) 4.67-4.79 (m, 1H) 6.51 (t, J=6.82 Hz, 1H) 7.45-7.57 (m, 2H) 7.97 (d, J=10.10 Hz, 1H) 8.41 (s, 1H) 8.65 (dd, J=7.33, 1.77 Hz, 1H). 13C NMR (100 MHz, DMSO-d6) δ ppm 21.58, 42.23, 44.60, 69.30, 106.47, 115.89, 116.31, 121.12, 122.00, 122.89, 131.50, 135.26, 139.85, 155.11, 155.49, 159.85. LRMS (ESI) m/z 383.1 [(M+H)]+, calc'd for C19H22N6O3: 382.43.

Provenance & Evidence