Isopropyl chloroformate → HCID 86696478, compound

Participants

Reaction Steps

To a stirred, ambient temperature, solution (1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate [113451-59-5] (1.0 g, 5.0 mmol) and Hunig's base [7087-68-5] (1.4 mL, 8.0 mmol) in ethyl acetate (120 mL) was slowly added a 1.0M solution of isopropyl chloroformate in toluene (5.1 mL) over the course of 10 minutes. The reaction was allowed to stir over night then was washed with brine, dried (MgSO4), and evaporated to obtain 1.3 g of yellow oil. LRMS (ESI) m/z 285.1 [(M+H)]+, calc'd for C14H24N2O4: 284.35.

Provenance & Evidence