Hydrochloric Acid → HCID 86696479, compound

Participants

Reaction Conditions

Reaction Steps

(1S,4S)-2-tert-Butyl 5-isopropyl 2,5-diazabicyclo[2.2.1]heptane-2,5-dicarboxylate (1.3 g, 4.6 mmol) was dissolved in methanol (200 mL). Concentrated hydrochloric acid (6 mL, 72 mmol) was added and the solution stirred at 50° C. for 2 h, then evaporated to dryness to provide (1S,4S)-isopropyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride as 0.9 g of white solid. LRMS (ESI) m/z 185.1 [(M+H)]+, calc'd for C9H16N202: 184.24.

Provenance & Evidence