HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 870793Generated: November 2, 2026
Potassium Hydroxide → 1-(2,2-Difluorobenzo[D][1,3]dioxol-5-YL)cyclopropanecarbonitrile
https://huagongshe.com/reaction/870793
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | 2,2-Difluoro-1,3-benzodioxole-5-acetonitrile | HCID 20311384 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2,2-Difluorobenzo[D][1,3]dioxol-5-YL)cyclopropanecarbonitrile | HCID 57446150 | — |
Reaction Steps
A mixture of (2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile (1.0 eq), 50 wt % aqueous KOH (5.0 eq) 1-bromo-2-chloroethane (1.5 eq), and Oct4NBr (0.02 eq) was heated at 70° C. for 1 hour. The reaction mixture was cooled, then worked up with MTBE and water. The organic phase was washed with water and brine. The solvent was removed to afford (2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969574B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-1f99abbd95204aca9723a67a4ce0c697 |
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| Source note | uspto-grants-2015_03 |
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