Hydroxyamine hydrochloride → 3-(1,3-Dioxolan-2-yl)thiophene-2-carbaldehyde oxime
Reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:10]=[CH:9][S:8][C:7]=1[CH:11]=O.Cl.[NH2:14][OH:15].C(=O)([O-])O.[Na+]>C(O)C.O>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:10]=[CH:9][S:8][C:7]=1[CH:11]=[N:14][OH:15]Participants
Procedure
3-(1,3-Dioxolan-2-yl)thiophene-2-carbaldehyde (13.1 g, 71.11 mmol), prepared by a method described by Hibino (S. Hibino et al., J. Org. Chem. 1984, 49, 5006), was dissolved in ethanol (80 ml). At room temperature a solution of hydroxylamine hydrochloride (two equivalents) and sodium hydrogencarbonate (one equivalent) in water (130 ml) was added and the resultant mixture stirred at this temperature for two hours. The ethanol was removed under reduced pressure and the aqueous phase extracted with ethyl acetate (3×300 ml). The combined organic layers were washed with brine and dried over sodium sulfate. Evaporation after filtration afforded 3-(1,3-dioxolan-2-yl)thiophene-2-carbaldehyde oxime as an off-white solid (quantitative). 1H NMR (2 isomers, 1:1) (CDCl3): δ 8.56 (1H, s), 8.45 (1H, s), 7.50 (1H, d, J 5.26), 7.25 (1H, d, J 5.2), 7.21 (1H, d, J 5.28), 7.12 (1H, d, J 5.2), 6.09 (1H, s), 5.99 (1H, s), 4.17–4.00 (2H, m).
Workup
- customThe ethanol was removed under reduced pressure
- extractionthe aqueous phase extracted with ethyl acetate (3×300 ml)
- washThe combined organic layers were washed with brine
- dry with materialdried over sodium sulfate
- customEvaporation
- filtrationafter filtration
Sources & evidence
- ORD record
- ord-40b3fdf101234a18a130f74ed6480c31
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07091209B2
Reaction notes
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