HCID 71621785, compound → HCID 86689230, compound

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3-[({[4-(aminocarbonyl)-3-(4-aminophenyl)isothiazol-5-yl]amino}carbonyl)amino]propyl acetate (10.0 g) and 10% palladium on carbon (3 g) in tetrahydrofuran (400 mL) and dimethylformamide (100 mL) was hydrogenated at 80 psi over 24 hr. in metal bomb. The catalyst was removed by filtration through celite and washed with tetrahydrofuran. The filtrate was concentrated in vacuo to give a yellow solid, which was stirred in ether (100 mL) and collected by filtration to give the title compound as a light yellow solid (8.8 g, 96%).

Provenance & Evidence