4-Methylphenyl isocyanate → HCID 71621787, compound

Participants

Reaction Steps

A mixture of 5-amino-3-(4-aminophenyl)isothiazole-4-carboxamide (25 mg, 0.11 mmol), N,N-diisopropylethylamine (0.047 mL, 0.27 mmol), and para-tolyl isocyanate (0.016 mL, 0.13 mmol) in 0.9 mL DCM was reacted at room temperature. After 1 hour an additional 0.006 mL para-tolyl isocyanate was added, and then 0.004 mL at 3.5 hrs. At 21 hours the reaction was quenched with 1 mL MeOH, stirred 10 min at rt, and then evaporated. The residue was triturated with EtOAc which afforded the title compound as a pale yellow solid (28 mg, 72%).

Provenance & Evidence