Sulfuric Acid → HCID 71621928, compound

Participants

Reaction Conditions

Reaction Steps

1-[4-cyano-3-(4-nitrophenyl)isothiazol-5-yl]-3-(3-pyrrolidin-1-ylpropyl)urea (36.0 g) was added portion wise to concentrated sulfuric acid (180.0 mL) at ambient temperature over 20 min. The resulting suspension was heated to 45° C. over 90 min. The reaction mixture was cooled to ambient temperature. The reaction mixture was poured into ice water (2000 ml), stirred for 30 min. The resulting mixture was made basic using ammonium hydroxide, filtered the solid and washed with water then dried in vacuo to give the title compound as off white solid (34.0 g, 90%).

Provenance & Evidence