HCID 71621928, compound → HCID 71621929, compound

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3-(4-nitrophenyl)-5-({[(3-pyrrolidin-1-ylpropyl)amino]carbonyl}amino)isothiazole-4-carboxamide (16.0 g,) and 10% palladium on carbon (6 g) in tetrahydrofuran (1500 mL) was hydrogenated at 80 psi over 24 hr in metal bomb. Filter the catalyst on celite and washed with tetrahydrofuran. The filtrate was concentrated in vacuo to give off white solid, which was stirred in ether (200 mL) and filtered to give the title compound as a white solid (13.8 g, 93%).

Provenance & Evidence