2-Fluoro-5-methylphenyl isocyanate → HCID 86689235, compound

Participants

Reaction Steps

A solution of 3-(4-amino-phenyl)-5-chloro-isothiazole-4-carbonitrile (4.565 g, 19.4 mmol) and 2-fluoro-5-methylphenyl isocyanate (5.85 g, 38.7 mmol) in 100 mL of dry THF was heated to reflux overnight. TLC indicated presence of considerable amount of starting material. Additional 2 g of 2-fluoro-5-methylphenyl isocyanate was added and the reaction was continued for another 24 h. The reaction was cooled to room temperature. THF was removed in vacuo and the resulting solid was stirred in 200 mL of Et2O for 1 h. Product was collected by filtration and washed with Et2O/hexanes to afford the title compound as a light yellow solid (6.78 g, 90%).

Provenance & Evidence