反应详情

To a mixture of 1-[4-(3-amino-4-cyanoisothiazol-5-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea (10.2 mg, 0.028 mmol) in 0.8 mL EtOH at rt was added 15 drops 1.0M aqueous NaOH, 7 drops 30% hydrogen peroxide and the reaction stirred at rt for 30 min, then heated at 60° C. After 2.5 hours an aqueous HCl (dilute) and EtOAc workup was done to give a light yellow solid. To this material was added an impure lot from another reaction, and the combined lots triturated with EtOAc to give the title compound as a pale yellow solid (26 mg, 93% combined yield).

1. temperatureheated at 60° C
2. customto give a light yellow solid
3. additionTo this material was added an impure lot
4. customfrom another reaction
5. customthe combined lots triturated with EtOAc