HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxypiperidine-1-carboxylate → N-(5-(azepan-4-yloxy)isothiazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | tert-Butyl 4-hydroxyazepane-1-carboxylate | HCID 22933363 | — |
| Reactant | 2-(2,6-Difluorophenyl)-1,3-thiazole-4-carboxylic acid | HCID 24278454 | — |
| Reactant | 5-Amino-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid | HCID 59455688 | — |
| Product | N-(5-(azepan-4-yloxy)isothiazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide | HCID 71261898 | — |
Reaction Steps
Following the procedure described in Example 1, and substituting Compound 1B2 in Step (1) with tert-butyl 4-hydroxyazepane-1-carboxylate (2B2) (200 mg, 0.93 mmol) and Compound 1E in Step 4 with 2-(2,6-difluorophenyl)thiazole-4-carboxylic acid (2E) (40 mg, 0.166 mmol), the title compound 2 (35 mg, 0.080 mmol) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969584B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-3f51e867898040a0961bbe345059ed64 |
| Source note | uspto-grants-2015_03 |