2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid → Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid	HCID 716091	—
Reactant	2-(2,6-Difluorophenyl)-1,3-thiazole-4-carboxylic acid	HCID 24278454	—
Reactant	Tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate	HCID 86720862	—
Product	Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate	HCID 86720861	89.3%

Reaction Steps

Following the procedure described in Step (3) of Example 6, and substituting Compounds 2E and 6D8 with 2-(pyridin-4-yl)thiazole-4-carboxylic acid (19E) (58 mg, 0.28 mmol) and tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate (31D3) (80 mg, 0.28 mmol) respectively, Compound 31A (120 mg, 0.25 mmol) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08969584B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-74bcf30c1b6648f49792e395565db9c8
Source note	uspto-grants-2015_03