Triphenylphosphine → HCID 178444930, compound

Participants

Reaction Conditions

Reaction Steps

A solution of [5-bromo-2-(2-ethyl-butoxy)-phenyl]-methanol, 2, (1.2 g 4.2 mmol), triphenylphosphine (1.6 g, 6 mmol), di-tert-butylazodicarboxylate (1.4 g, 6 mmol) and 3-methylpyrazolyl-5-one (0.75 g, 7.7 mmol) in a mixture of THF (5 mL) and toluene (10 ml) was heated at 120° C. in an Emrys microwave reactor for 20 min. The volatiles were removed in vacuo. The crude product was purified on silica to yield 1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazol-3-ol, 3.

Provenance & Evidence