Ethyl bromoacetate → HCID 86688755, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazol-3-ol, 3, 0.06 g (0.15 mmol) in acetone (3 mL) was added ethylbromoacetate (24 μL 0.22 mmol), K2CO3 (0.03 g, 0.22 mmol) and tetrabutylammonium iodide (0.008 g, 0.022 mmol). The resulting mixture was heated at 120° C. in an Emrys microwave reactor for 20 min. The volatiles were removed in vacuo and the crude product was purified on silica to yield to {1-[5-Bromo-2-(2-ethyl-butoxy)-benzyl]-1H-pyrazol-3-yloxy}-acetic acid ethyl ester, 4.

Provenance & Evidence