Hydrochloric Acid → HCID 67124134, compound

Participants

Reaction Steps

KY-560 In a round bottom flask equipped with gas inlet and magnetic stirrer were placed Biphenyl (2.1 gr, 13.65 mmol), Aluminum trichloride (1.5 gr, 11.25 mmol), and 150 ml of tetrachloroethane (TCM). While the TCM solution was stirring, a solution of 25 ml of tetrachloroethane and 0.830 ml of (4-Methoxy-phenyl)-acetyl chloride (5.5 mmol) was dropwise over five minutes by syringe. The reaction mixture was stirred 3-4 h. 150 ml of water and 5 ml of HCl were slowly added. The layers were separated. The aqueous layer was extracted with DCM. The combined DCM and TCE solution was washed with a saturated solution of NaCl in water. The organic solution was dried over Na2SO4. filtration followed by rotary evaporation produced a dark yellow solid. Chromatography on flash chromatographic (CycloHexane:DCM). Yield 1.2 gr (71%) as a white solid.

Provenance & Evidence