Hydrazine hydrate (1:1) → HCID 90408190, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 12A (1.777 g, 5.45 mmol) in methanol (30 mL) was added hydrazine hydrate (0.74 g, 15.26 mmol), followed by 50% Raney® nickel in water (200 mg) and the mixture was heated at 50° C. for 60 minutes. After cooling, diatomaceous earth was added and the slurry was filtered through diatomaceous earth with dichloromethane. Concentration provided the crude title compound which was used without further purification. MS (ESI) m/z 295.9 (M+H)+.

Provenance & Evidence