Sodium Hydroxide → HCID 58893385, compound

Participants

Reaction Steps

A mixture of Example 14A (6.500 g, 13.32 mmol) and 20% sodium hydroxide (6 mL) in dioxane (80 mL) was heated at 90° C. for 7 hours. The mixture was concentrated and the residue was treated with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate, filtered, and concentrated. The precipitate was filtered, washed with ethyl acetate/ether and dried under vacuum to give of the title compound. The filtrate was concentrated and purified by flash chromatography on silica (ISCO Companion), eluting with a gradient of 3:7 to 2:8 heptanes/ethyl acetate to give an additional quantity of the title compound. MS (ESI+) m/z 333.9 (M+H)+.

Provenance & Evidence