HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 56953824, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 56953824 | HCID 56953824 | — |
Reaction Steps
In a particular embodiment according to the present invention, compound of formula (D′) wherein R2 and R3 are methyl, herein after referred to as (D1), is reacted with benzylamine in methyl tert-butyl ether, dichloromethane, tetrahydrofuran (THF), Me-THF, or ethyl acetate in the presence of isobutyl chloroformate and N-methylmorpholine to afford (Z)-2-acetamido-N-benzyl-3-methoxyacrylamide (A1), as shown in the following scheme 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969620B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-484bd4113a7b4459b5fac69e89ed7480 |
| Source note | uspto-grants-2015_03 |