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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 871230Generated: October 27, 2026

4-Chloro-5-methylquinazoline → 1-(5-Tert-butyl isoxazol-3-yl)-3-(3-(5-methylquinazolin-4-yloxy)phenyl)urea

https://huagongshe.com/reaction/871230

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-5-methylquinazolineHCID 13495576—
Reactant1-(5-Tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)ureaHCID 66876595—
Product1-(5-Tert-butyl isoxazol-3-yl)-3-(3-(5-methylquinazolin-4-yloxy)phenyl)ureaHCID 44243178—

Reaction Steps

To 1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea from Example 1A (83 mg, 0.3 mmol) was added 4-chloro-5-methylquinazoline from the previous step (53 mg, 0.3 mmol) using the procedure described in Example 1B Step 1, to afford the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08969587B2
Source datasetuspto-grants-2015_03
ORD IDord-a1623922c4e74b21ae677ac175061201
Source noteuspto-grants-2015_03