1-(5-Tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea → HCID 58267894, compound

HRID 871244Notes

Reaction equation

HRID 871244 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=2)=[O:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].O[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([CH3:32])[CH:30]=2)[N:25]=[CH:24][N:23]=1>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[C:29]([CH3:32])[CH:30]=4)[N:25]=[CH:24][N:23]=3)[CH:15]=2)=[O:12])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 668765951-(5-Tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)ureaHCID 178423420HCID 178423420, compound

Product 1

HCID 58267894HCID 58267894, compound

Procedure

The title compound was prepared using 1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea from Example 1A (83 mg, 0.3 mmol) and 4-hydroxy-6-methylquinazoline from the previous step (53 mg, 0.3 mmol) according to the procedure described in Example 1B Step 1 to afford 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methylquinazolin-4-yloxy)phenyl)urea.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-345077b50bf2458c8c7655df178d30c0
Source dataset
uspto-grants-2015_03
Patent number
US08969587B2

Reaction notes

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