1,4-Dioxane hydrochloride → 1-(5-Tert-butylisoxazol-3-yl)-3-{3-[6-methoxy-7-(piperidin-4-yloxy)quinazolin-4-yloxy]phenyl}urea
Reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11](=[O:46])[NH:12][C:13]2[CH:14]=[C:15]([CH:43]=[CH:44][CH:45]=2)[O:16][C:17]2[C:26]3[C:21](=[CH:22][C:23]([O:29][CH:30]4[CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31]4)=[C:24]([O:27][CH3:28])[CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.O1CCOCC1>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:12][C:13]2[CH:45]=[CH:44][CH:43]=[C:15]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:29][CH:30]5[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]5)=[C:24]([O:27][CH3:28])[CH:25]=4)[N:20]=[CH:19][N:18]=3)[CH:14]=2)=[O:46])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
Using the procedure described in Example 103B, tert-butyl 4-(4-{3-[3-(5-tert-butylisoxazol-3-yl)ureido]phenoxy}-6-methoxyquinazolin-7-yloxy)piperidine-1-carboxylate was reacted with 4.0 M HCl/1,4-dioxane at room temperature for 6 hours, to afford 1-(5-tert-butylisoxazol-3-yl)-3-{3-[6-methoxy-7-(piperidin-4-yloxy)quinazolin-4-yloxy]phenyl}urea as a crude product. LC-MS (ESI) m/z 533 (M+H)+.
Sources & evidence
- ORD record
- ord-7526cd3ea0744379b25b0b07e4dd0339
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08969587B2
Reaction notes
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