Phenyl 3-isopropylisoxazol-5-ylcarbamate → HCID 59394730, compound

HRID 871459Notes

Reaction equation

HRID 871459 reaction equation
[CH3:1][C:2]1([C:5]2[O:9][N:8]=[C:7]([NH2:10])[CH:6]=2)[CH2:4][CH2:3]1.C(C1C=C(N[C:20](=[O:28])[O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)ON=1)(C)C>>[CH3:1][C:2]1([C:5]2[O:9][N:8]=[C:7]([NH:10][C:20](=[O:28])[O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:6]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 13489689Phenyl 3-isopropylisoxazol-5-ylcarbamateHCID 2040703795924-26-8

Product 1

HCID 59394730HCID 59394730, compoundYield 70%

Procedure

Prepared from 5-(1-methylcyclopropyl)isoxazol-3-amine (80 mg, 0.58 mmol) according to the method described for phenyl 3-isopropylisoxazol-5-ylcarbamate in Example 122A Step 3, to afford phenyl 5-(1-methylcyclopropyl)isoxazol-3-ylcarbamate as a colorless solid (105 mg, 70%). 1H NMR (300 MHz, CDCl3) δ 7.87 (brs, 1H), 7.39-7.44 (m, 2H), 7.18-7.29 (m, 3H), 6.52 (s, 1H), 1.58 (s, 3H), 1.20-1.24 (m, 2H), 0.84-0.87 (m, 2H); LC-MS (ESI) m/z 259 (M+H)+.

Sources & evidence

ORD record
ord-a387915211484534837f688bbe9f9dfc
Source dataset
uspto-grants-2015_03
Patent number
US08969587B2

Reaction notes

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