Phenyl 3-isopropylisoxazol-5-ylcarbamate → Phenyl 3-(1-methoxy-2-methylpropan-2-yl)isoxazol-5-ylcarbamate

HRID 871463Notes

Reaction equation

HRID 871463 reaction equation
[CH3:1][O:2][CH2:3][C:4]([C:7]1[CH:11]=[C:10]([NH2:12])[O:9][N:8]=1)([CH3:6])[CH3:5].C(C1C=C(N[C:22](=[O:30])[O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)ON=1)(C)C>>[CH3:1][O:2][CH2:3][C:4]([C:7]1[CH:11]=[C:10]([NH:12][C:22](=[O:30])[O:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[O:9][N:8]=1)([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 13489689Phenyl 3-isopropylisoxazol-5-ylcarbamateHCID 534418093-(1-Methoxy-2-methylpropan-2-YL)isoxazol-5-amine

Product 1

HCID 66876218Phenyl 3-(1-methoxy-2-methylpropan-2-yl)isoxazol-5-ylcarbamate

Procedure

Prepared from 3-(1-methoxy-2-methylpropan-2-yl)isoxazol-5-amine (100 mg, 0.59 mmol) according to the method described for phenyl 3-isopropylisoxazol-5-ylcarbamate in Example 122A Step 3, to afford phenyl 3-(1-methoxy-2-methylpropan-2-yl)isoxazol-5-ylcarbamate as an oil that was not purified further.

Sources & evidence

ORD record
ord-00c465feb801499387a779c2b6c8e5ee
Source dataset
uspto-grants-2015_03
Patent number
US08969587B2

Reaction notes

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