4-(3-Nitro-5-trifluoromethyl-benzoyl)-morpholine → Morpholine, 4-[3-amino-5-(trifluoromethyl)benzoyl]-

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Reaction Steps

Morpholin-4-yl-(3-nitro-5-trifluoromethyl-phenyl)-methanone (800 mg, 2.6 mmoles) from the previous step was dissolved in 40 mL of ethyl acetate. To this solution was added 10% palladium on carbon, the reaction was stirred under hydrogen at room temperature overnight. The solution filtered through celite and concentrated to give 3-(morpholine-4-carbonyl)-5-(trifluoromethyl)phenylamine (688 mg). 1H NMR (300 MHz, DMSO-d6) δ 6.90 (s, 1H), 6.75 (d, 2H), 5.6 (b, 6H).

Provenance & Evidence