Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Tolylhydrazinium(1+) chloride → 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Tolylhydrazinium(1+) chloride | HCID 71562 | — |
| 반응물 | 4,4,4-Trifluoro-3-oxobutanenitrile | HCID 13843540 | — |
| 생성물 | 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-amine | HCID 66876804 | 22% |
반응 단계
Following the procedure in Example 161A Step 3, m-tolylhydrazine hydrochloride (1.15 g, 7.30 mmol) and 4,4,4-trifluoro-3-oxobutanenitrile (1.0 g, 7.30 mmol) were reacted to give 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-amine (380 mg, 1.57 mmol, 22%). 1H NMR (300 MHz, DMSO-d6) δ 7.60-7.20 (m, 4H), 5.82-5.61 (m, 3H), 2.59 (s, 3H); LC-MS (ESI) m/z 242 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08969587B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-5e624a5c794b4680b1e0271d7764a5bd |
| 출처 메모 | uspto-grants-2015_03 |