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Phenyl chloroformate → phenyl 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl chloroformate | HCID 15891 | — |
| 反応物 | 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-amine | HCID 66876804 | — |
| 生成物 | phenyl 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-ylcarbamate | HCID 66876129 | 58% |
反応手順
Following the procedure in Example 118A, 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-amine (380 mg, 1.58 mmol) and phenyl chloroformate (0.60 mL, 4.74 mmol) were reacted to give phenyl 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-ylcarbamate (330 mg, 0.91 mmol, 58%). 1H NMR (300 MHz, DMSO-d6) δ 10.4 (br s, 1H), 7.62-6.85 (m, 10H), 2.46 (s, 3H); LC-MS (ESI) m/z 362 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08969587B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-f21fc6f31b0d46ceacd3edd0a71a17ff |
| 出典メモ | uspto-grants-2015_03 |