4-Aminophenol → HCID 53303292, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.40 g (1.29 mmol) of the product obtained in step 1.5 in 4 mL of anhydrous DMSO is added 0.160 g (1.47 mmol) of 4-aminophenol. The reaction mixture is heated at 110°C. overnight and then evaporated to dryness. The solid residue is purified by chromatography on silica gel, eluting with a dichloromethane/methanol gradient (100/0 to 90/10). 0.090 g of the expected product is obtained in the form of an off-white solid. Yield=20%. m.p. >260°C. M+H+=341.

Provenance & Evidence