反应详情

4.27 g (12.77 mmol) of the product prepared in step 4.2 in 130 mL of an ethyl acetate/ethanol mixture (v/v=1/1) are placed in a hydrogenation autoclave, and 0.54 g of 10% palladium-on-charcoal is added, under an inert atmosphere. The mixture is stirred under a hydrogen pressure of 3 bar at room temperature. After filtration through thin glass fibre paper and evaporation under reduced pressure, 3.87 g of the expected product are obtained in the form of a pink solid, which is used as obtained in the following step. Yield=99%.

1. additionis added, under an inert atmosphere
2. filtrationAfter filtration
3. customthrough thin glass fibre paper and evaporation under reduced pressure, 3.87 g of the expected product
4. customare obtained in the form of a pink solid, which
5. customas obtained in the following step