HCID 67326287, compound → HCID 67324955, compound

Participants

Reaction Steps

1.65 g (5.0 mmol) of the product prepared in step 16.2 are placed in 120 mL of an ethanol/acetic acid mixture (v/v=1/1) in a hydrogenation autoclave, and 0.150 g of platinum (IV) oxide is added, under an inert atmosphere. The mixture is stirred under a hydrogen pressure of 4 bar at room temperature for 4 hours. After filtering through thin glass fibre paper and evaporating to dryness under reduced pressure, the oily residue is taken up in chloroform and washed with aqueous 1N NaOH solution. The organic phase is dried over Na2SO4, filtered and concentrated under vacuum. 1.5 g of the expected product are obtained in the form of a brown oil, which is used as obtained in the following step. Crude yield=quantitative.

Provenance & Evidence