反应详情

A mixture containing 3.98 g (13.75 mmol) of the product prepared in step 20.1, 34.4 mL (34.4 mmol) of 1N NaOH and 35 mL of ethanol is stirred at room temperature overnight. The ethanol is evaporated off under reduced pressure and the residue is diluted in 100 mL of water. 65 mL of aqueous 1N HCl solution are added and the precipitate formed is drained by suction. The solid is rinsed with water and dried under vacuum. 2.88 g of the expected product are obtained in the form of a beige-coloured solid. Yield=92%.

1. customThe ethanol is evaporated off under reduced pressure
2. additionthe residue is diluted in 100 mL of water
3. addition65 mL of aqueous 1N HCl solution are added
4. customthe precipitate formed
5. washThe solid is rinsed with water
6. customdried under vacuum