Potassium Carbonate → HCID 67325957, compound

Participants

Reaction Steps

To a suspension of 0.29 g (0.54 mmol) of the product prepared in step 22.1 in 9 mL of anhydrous methanol is added 0.37 g (2.68 mmol) of K2CO3, and the mixture is refluxed for 1 hour. It is evaporated to dryness and the residue is taken up in water and CH2Cl2. The organic phase is dried over MgSO4, filtered and concentrated under vacuum. The crude product is purified by chromatography on a column of silica, eluting with a dichloromethane/methanol gradient (90/10). After triturating in methanol, 0.22 g of the expected product is finally obtained in the form of a yellow solid. Yield=78%.

Provenance & Evidence