2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-hydroxymethyl-2H-pyridazin-3-one

HRID 87190Notes

Reaction equation

HRID 87190 reaction equation
[C:32](=[O:33])([OH:34])[c:35]1[c:36](=[O:60])[n:37]([CH2:50][CH2:51][CH2:52][c:53]2[cH:54][cH:55][c:56]([F:59])[cH:57][cH:58]2)[n:38][c:39](-[c:41]2[cH:42][c:43]([F:49])[c:44]([O:47][CH3:48])[cH:45][cH:46]2)[cH:40]1.[F:1][c:2]1[cH:3][c:4]([F:5])[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([CH2:12][N:13]2[C:14](=[O:15])[c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[C:22]2=[O:23])[c:24](=[O:25])[n:26]([CH2:27][CH:28]([CH3:29])[CH3:30])[n:31]1>>[CH2:32]([OH:33])[c:35]1[c:36](=[O:60])[n:37]([CH2:50][CH2:51][CH2:52][c:53]2[cH:54][cH:55][c:56]([F:59])[cH:57][cH:58]2)[n:38][c:39](-[c:41]2[cH:42][c:43]([F:49])[c:44]([O:47][CH3:48])[cH:45][cH:46]2)[cH:40]1

Participants

3

Reactant 2

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-oneHCID 219916374-carboxy-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-one

Product 1

HCID 219915096-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-hydroxymethyl-2H-pyridazin-3-one

Sources & evidence

ORD record
ord-3643b16ce1ca4047b5687a7f7f2485e4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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