HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Bromothiophene-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Bromothiophene-2-carboxylic acid | HCID 349115 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-Bromothiophene-2-carbonyl chloride | HCID 605712 | 99.1% |
Reaction Steps
A mixture of 5-bromothiophene-2-carboxylic acid (300 mg, 1.45 mmol), thionyl chloride (423 μL, 5.80 mmol), and N,N-dimethylformamide (1 drop) was dissolved in chloroform (3 mL), and refluxed for 1 hour. After cooling down, the reaction mixture was concentrated under reduced pressure to give the titled reference compound (324 mg) as a pale yellow solid. (Yield 99%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975256B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-d0ce89272be544318855abbabb7461bd |
| Source note | uspto-grants-2015_03 |