Diisopropylethylamine → HCID 25124583, compound

Participants

Reaction Steps

10% Palladium-carbon (20 mg) was added to a solution of (2R)—N-{[3-chloro-1-(3-methoxypropyl)-1H-indol-6-yl]methyl}-N-cyclopropylmorpholin-2-carboxamide (67 mg) and diisopropylethylamine (43 mg) in ethanol (3 ml) and the mixture was stirred under hydrogen atmosphere at room temperature for 8 hours. Insoluble materials were filtered and the filtrate was concentrated in vacuo. The resulted residue was dissolved in ethyl acetate, washed with a saturated aqueous solution of sodium bicarbonate and saturated brine successively, dried over magnesium sulfate and concentrated in vacuo. The resulted residue was purified with NH-silica gel column chromatography (eluting solvent: ethyl acetate to ethyl acetate/methanol=10/1) to give (2R)—N-cyclopropyl-N-{[1-(3-methoxypropyl)-1H-indol-6-yl]methyl}morpholin-2-carboxamide (53 mg) as a colorless oil.

Provenance & Evidence