Cyclopropylamine → N-[4-(benzyloxy)-3-(3-methoxypropoxy)benzyl]cyclopropanamine

HRID 872009Notes

Reaction equation

HRID 872009 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][C:10]=1[O:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:23]1([NH2:26])[CH2:25][CH2:24]1>>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH:26][CH:23]2[CH2:25][CH2:24]2)=[CH:11][C:10]=1[O:17][CH2:18][CH2:19][CH2:20][O:21][CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 214586084-(Benzyloxy)-3-(3-methoxypropoxy)benzaldehyde

Product 1

HCID 59494923N-[4-(benzyloxy)-3-(3-methoxypropoxy)benzyl]cyclopropanamine

Procedure

4-(Benzyloxy)-3-(3-methoxypropoxy)benzaldehyde (945 mg) and cyclopropylamine (0.44 ml) were treated in the same manner as Reference Example 1 to give N-[4-(benzyloxy)-3-(3-methoxypropoxy)benzyl]cyclopropanamine (947 mg) as a colorless oil.

Sources & evidence

ORD record
ord-21e83ad301d646a3a297842f1aa72b8a
Source dataset
uspto-grants-2015_03
Patent number
US08975252B2

Reaction notes

Loading…