Hydrochloric Acid → HCID 67541868, compound

Participants

Reaction Steps

5N Aqueous solution of sodium hydroxide (3.4 ml) was added to a solution of ethyl 4-(3-methoxypropyl)-2-naphthoate (2.41 g) in ethanol and the mixture was stirred at room temperature for 3 hours. The reaction solution was acidified by adding 10% hydrochloric acid under ice-cooling and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate and concentrated in vacuo. The resulted residue was triturated in n-hexane to give 4-(3-methoxypropyl)-2-naphthoic acid (2.09 g) as a colorless powder.

Provenance & Evidence