HCID 59494498, compound → HCID 59494704, compound

Participants

Reaction Steps

20% Palladium hydroxide-carbon (dry) (22 mg) was added to a solution of tert-butyl(2S,6R)-2-[(benzyloxy)methyl]-6-({cyclopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}carbonyl)morpholin-4-carboxylate (220 mg) in methanol and the mixture was stirred under normal pressure of hydrogen atmosphere at room temperature for 6 hours. After filtration of insoluble materials through Celite, the filtrate was concentrated to give tert-butyl(2R,6S)-2-({cyclopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]amino}carbonyl)-6-(hydroxymethyl)morpholin-4-carboxylate (200 mg) as a pale yellow oil.

Provenance & Evidence