N-bromobutanimide → HCID 59494875, compound

Participants

Reaction Steps

N-Bromosuccinimide (1.04 g) was added to a solution of [4-(3-methoxypropoxy)-2,3-dihydro-1-benzofuran-6-yl]methanol (1.27 g) in dichloromethane (25 ml) under ice-cooling and the mixture was stirred at the same temperature for 30 minutes. The reaction mixture was concentrated in vacuo and the resulted residue was purified with a silica gel column chromatography (eluting solvent: n-hexane/ethyl acetate=3/2) to give [5-bromo-4-(3-methoxypropoxy)-2,3-dihydro-1-benzofuran-6-yl]methanol (860 mg) and [7-bromo-4-(3-methoxypropoxy)-2,3-dihydro-1-benzofuran-6-yl]methanol (540 mg) as a colorless oil.

Provenance & Evidence