Chlorosuccinimide → HCID 59494031, compound

Participants

Reaction Conditions

Reaction Steps

N-Chlorosuccinimide (110 mg) was added to a solution of tert-butyl cyclopropyl[4-methoxy-3-(3-methoxypropoxy)benzyl]carbamate (300 mg) in acetonitrile (5.0 ml) under ice cooling and the mixture was stirred at room temperature for an hour and at 75° C. for 5 hours. The reaction mixture was concentrated in vacuo and the resulted residue was purified with a NH-silica gel column chromatography (eluting solvent: n-hexane/ethyl acetate=10/1 to 3/1) to give tert-butyl [2-chloro-4-methoxy-5-(3-methoxypropoxy)benzyl]cyclopropylcarbamate (265 mg) as a colorless oil.

Provenance & Evidence