Ethyl benzoylacetate → HCID 136409078, compound

Participants

Reaction Steps

3-Methyl-4-(3,4-methylenedioxyphenyl)-1H-pyrazol-5-amine (300 mg) and ethyl 3-phenyl-3-oxopropanoate (318 mg) are stirred overnight in a pyridine (10 mL) solvent at 95° C. After cooling to room temperature, the reaction solvent is removed by distillation under reduced pressure. The remainder is extracted with ethyl acetate and water. The extracted organic layer is washed with brine and dehydrated with anhydrous MgSO4. The dehydrated organic layer is distilled under reduced pressure 330 mg of the target compound is yielded by column chromatography.

Provenance & Evidence