Diisopropylethylamine → HCID 66635662, compound

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Reaction Steps

5-Chloro-7-(3-methylphenyl)-3-iodo-2-methylpyrazolo[1,5-a]pyrimidine (580 mg), DIPEA (0.4 mL) and (S)-2-pyrrolidinemethanol (400 mg) are stirred at 90° C. in an acetonitrile (60 mL) solvent for 6 hours. The reaction solvent is removed by distillation under reduced pressure. The remainder is purified by column chromatography to yield the target compound (360 mg). 1H NMR (CDCl3, 300 MHz): δ 7.67 (m, 2H), 7.40 (m, 2H), 7.27 (s, 1H), 6.10 (s, 1H), 4.48 (br, 1H), 3.88-3.55 (m, 4H), 2.44 (s, 3H), 2.38 (s, 3H), 2.08-1.97 (m, 3H), 1.76 (m, 1H).

Provenance & Evidence