Diisopropylethylamine → HCID 86688021, compound

Participants

Reaction Steps

5-Chloro-2-(ethoxymethyl)-7-(4-fluorophenyl)-3-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine (22 mg), DIPEA (0.1 mL) and N-methylaminoethanol (0.1 mL) are stirred for 12 hours in an acetonitrile (7 mL) solvent at 84° C. The reaction solvent is removed by distillation under reduced pressure. The remainder is extracted with ethyl acetate and water. The collected organic layer is washed with brine and dehydrated with anhydrous MgSO4. The solvent is removed by distillation under reduced pressure and the remainder is purified by column chromatography to yield the target compound (18 mg).

Provenance & Evidence