2-Aminopyrimidine → 6-Chloro-2-methyl-4-(pyrimidin-4-ylamino)pyridazin-3(2H)-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Aminopyrimidine	HCID 7978	—
Edukt	6-chloro-4-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamino)pyridazin-3(2H)-one	HCID 58540316	—
Edukt	4-Bromo-6-chloro-2-methyl-2,3-dihydropyridazin-3-one	HCID 59216474	—
Produkt	6-Chloro-2-methyl-4-(pyrimidin-4-ylamino)pyridazin-3(2H)-one	HCID 66610237	69%

Reaktionsschritte

Using the same general procedure as described for the preparation of 101m, reaction of 2-aminopyrimidine (450 mg, 4.74 mmol) with 103a (1.06 g, 4.74 mmol) afforded 103b in 69% yield (745 mg) as an amorphous yellow solid: mp 233-235° C.; 1H NMR (300 MHz, DMSO-d6) δ 10.05 (s, 1H), 8.92 (d, J=1.0 Hz, 1H), 8.54 (d, J=5.5 Hz, 1H), 8.45 (s, 1H), 7.58 (dd, J=6.0, 1.0 Hz, 1H), 3.70 (s, 3H); MS (ESI+) m/z 238.0 (M+H).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08975260B2
Quelldatensatz	uspto-grants-2015_03
ORD ID	ord-736cc5ecd6ec451e923a3bbf3b35c2f8
Quellennotiz	uspto-grants-2015_03